By the 15th century, he had found a secure place in the arms and hearts of French aristocrats. During the reign of Henry VIII, Maltese arrived in the British Isles. By the end of the 16th century, the Maltese had become a favorite pet for noble and royal ladies. The little dog was a favorite of Queen Elizabeth I, Mary Queen of Scots, and Queen Victoria. Numerous painters, including Goya and Sir Joshua Reynolds, included these small dogs in their portraits of beautiful women.

Although he survived the fall of the Roman Empire and the Dark Ages, the Maltese was nearly destroyed in the 17th and 18th centuries when attempts were made to breed him to be the size of a squirrel. After this nearly disastrous experiment, breeders mixed poodles, miniature spaniels, and East Asian miniature dogs with the breed to save it. This resulted in the Maltese becoming so varied that several new breeds were formed. It is thought by many that Maltese are the direct ancestors of the Bichon Frise, Bolognese and Havanese breeds.

The number of Maltese dogs registered with the AKC grew very slowly until the 1950s. Since then, the breed has become quite popular. Maltese are one of the most popular breeds among spectators at dog shows, and frequently win the Toy Group. They also have an excellent record in the “Best in Show” competition.